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Science

Identification of tofacitinib, Filgotinib and Ruxolitinib on experimental Sjögren's syndrome model in mice

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Science

Establishment and Optimization of scRNA-seq assay to find the mechanism of immune therapy against tumors

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Science

Tumor evolution inactivates microRNA machinery for immune evasion

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Science

Establishment of In vitro Human T cell Exhaustion Model to Enable High Throughput

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Science

Myeloid-dominated spontaneous tumor models as the tool for the evaluation of immune modulators

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Science

Construction of Siglec-15 knockout mouse model and validating the effect of Siglec-15 KO on T cell response

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Science

Establishment of KRAS-G12C inhibitor induced resistant tumor models enable the development of new generation KRAS-G12C inhibitors and combinatorial strategies

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Science

Establishment of KRAS G12C mutant patient-derived xenograft (PDX) models for pre-clinical evaluation of KRAS G12C targeted anticancer therapy

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Science

Validation of GVHD in mouse model for preclinical efficacy screen

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Science

Engineered cell line panel complemented with in vivo models to enable next-generation target therapy discovery in cancer

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Science

Establishment of drug induced resistant tumor models enable the development of next generation anticancer therapeutics

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Science

CRISPR library screens identify frequent cancer mutations regulating PD-1 blockade response

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Science

Outsourcing Drug Discovery And Development

Considerations for emerging biophama companies

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Science

How Diversity In Therapeutic Strategies Is Expanding The Drug Discovery Toolbox

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Science

Bifunctional Molecules: A Diverse New Modality That Unlocks New Target Classes

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Science

CRISPR Library Screen: A Powerful Tool For Identifying Novel Tumor Targets

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Science

CRISPR Cas9 library screen in primary T cells diffuse large B cell lymphoma cells to identify modulators in tumor-immune interaction

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Science

Inflammasome Activation in M2 Macrophage Restrain the Immune Supperssive Function

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Science

Validation of the Combinatorial Effect of Blinatumomab and Nivolumab in Caner Therapy

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Science

Enabling Technology for Targeted Protein Degradation

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Interview

Unlocking the potential of DEL | Inspire Hit Discovery

Interview of Dr. Xuanjia Peng

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Science

Faster with high-speed fragment screening —Accelerate your drug discovery campaign

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Science

Magical Power of QM

To Empower Organic Syntheses

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Interview

Drug Hunter: Discovering New Frontiers in Cancer Treatments & Beyond

Interview of Dr. Phil Jones, VP of Therapeutics Discovery

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Science

Specialty Chemistry Platform and Capabilities at WuXi AppTec RSD

Cutting-edge synthetic technology and expertise in special chemical matters

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Interview

Merging a Passion for Biochemistry, Synthetic Chemistry, and Bioactive Molecules in Academia

Interview of Dr. Joseph Ready, Co-Founder, Rodeo

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Science

In vivo CRISPR Animal Models 

High efficiency genome editing service for drug discovery

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Science

Empowering Chemistry with Quantum Mechanics

WuXi’s RSD teams are applying and developing QM calculations in multiple areas for organic syntheses

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Interview

Shifting the Paradigm of Resistance and Undruggables for Unmet Medical Needs in Cancer, Neuroscience, and Beyond

Interview of John Houston, Arvinas

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Science

DELopen: DNA Encoded Library (DEL) Platform Offering more than 2.8 Billion Compounds

Apply for DNA-Encoded Library compound for free

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Science

OncoWuXi Database: To Facilitate Oncology Drug Discovery and Translational Oncology

Providing a portable oncology database for selection and inquiry of 1,000+ models for cancer research

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Interview

DELopen Promotes Worldwide Academic Research Using DNA-Encoded Libraries, Far More Than Just a Numbers Game

Interview of Dr. Richard Lerner

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