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Translational Oncology Biomarker discovery Human tumor bank Mouse clinical trial 67 PDX-derived primary cancer cell lines Drug-resistant PDX models Combination therapy platform including radiation World leading genome sequencing and bioinformatics capability In Vitro Pharmacodynamic Capability ELISA (enzyme-linked immunosorbent assay). Western blotting. Regular PCR and qPCR (real-time quantitative PCR). Biomarker Discovery with IHC (immunohistochemistry) Instrument platforms:1)Automated Station/Leica Autostainer XL. 2)Vectra, PerkinElmer (caliper). 3)Fluorescence Microscope/Axio Imager A2 & Nikon NI-U Opal multiplex IHC platform DNA FISH Assay DNA FISH technique and its clinical application Workflow of DNA FISH HER2, EGFR, and other FISH on FFPE slides DNA FISH on blood sample Combination Therapy Platform including Radiation Radiation baseline in syngeneic models Radiation was recently considered to be promising in combination with immunotherapy, based on its capacity of mobilizing immune responses RadSource RS2000/XE X-ray irradiator suitable for small animal use 2 syngeneic models with radiation therapy data Radiation baseline in PDX models 21 PDX models with radiation therapy data Case study: combination therapy with radiation Breast cancer model: BR-05-0028 MLN4924, a NAE inhibitor, showed synergetic effect with focal radiation PDX Derived Human Cancer Cell Lines (PCC) 67 human cancer cell lines generated from PDX models With matched PDX models Cancer stem cell (CSC) features 64/67 form xenografts in mice which recapitulate pathology of the original patient tumor Genomic profiling data available Drug-resistant PDX Resistance was induced by repeated treatment Genomic profiling data available for erlotinib and crizotinib resistant NSCLC models Erlotinib Resistant Lung Cancer PDX Harboring EGFRL858R LU-01-0055 PDX harboring EGFRL858R Sensitive to erlotinib Erlotinib resistant LU- 01-0055R Afatinib overcame the erlotinib resistance Learn More About Oncology & Immunology CRISPR/Cas9 Gene Editing Tumor Models Immuno-oncology Biomarker Autoimmune and Inflammatory Animal Models OncoWuXi Database Business Contact: North America: Declan Ryan, declan.ryan@wuxiapptec.com Europe and Israel: Dave Madge, dave_madge@wuxiapptec.com China: Marcher Xu, xu_longji@wuxiapptec.com Japan: Yan Zhu, yan_zhu@wuxiapptec.com Korea: Suk Young Cho, sycho@wuxiapptec.com