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High Efficiency Genome Editing Service for Drug Discovery From genome editing to disease models and PK-PD-efficacy studies In Vivo CRISPR Platform for Rare Disease Well-established in vivo gene editing platform in rodent Generation of genetically engineered animal models (GEAM) for drug discovery in rare disease 30+ knockin and knockout mouse lines generated last year Efficacy Evaluation and MoA Research Platform Well-established in vitro, ex vivo and in vivo bioassay platforms Multiple routes for drug administration, animal and tissue manipulation and histopathology Knockout Services CRISPR/CAS9 based knockout in mouse, rat ES cell based knockout in mouse Knockin Services CRISPR/CAS9 based knockin in mouse, rat ES cell based knockin in mouse Humanization Services In situ replace mouse gene with matched human exons or introns Express human cDNA under the control of mouse promoter Transgenic Services Random integration into genome Targeted transgene into Rosa26 or other site Genotyping and Phenotyping Services Analyze the genotype of mice and cells by PCR, Southern Blot or NGS Characterization of disease mouse models Other Services In vitro fertilization Embryo and sperm cryopreservation Compliance and Accreditations AAALAC accredited facility OECD – received a statement of GLP compliance from the Belgium regulatory authorities Chinese SFDA – received certificate of GLP compliance WuXi has conducted IND and NDA enabling studies for submission to the US FDA Business Contact： North America: Declan Ryan, declan.ryan@wuxiapptec.com Europe and Israel: Dave Madge, dave_madge@wuxiapptec.com China: Marcher Xu, xu_longji@wuxiapptec.com Japan: Yan Zhu, yan_zhu@wuxiapptec.com Korea: Suk Young Cho, sycho@wuxiapptec.com
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