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In vivo CRISPR animal models and services

High Efficiency Genome Editing Service for Drug Discovery

 

From genome editing to disease models and PK-PD-efficacy studies

 

 

In Vivo CRISPR Platform for Rare Disease

 

  • Well-established in vivo gene editing platform in rodent
  • Generation of genetically engineered animal models (GEAM) for drug discovery in rare disease
  • 30+ knockin and knockout mouse lines generated last year

 

 

Efficacy Evaluation and MoA Research Platform

 

  • Well-established in vitro, ex vivo and in vivo bioassay platforms
  • Multiple routes for drug administration, animal and tissue manipulation and histopathology

 

 

Knockout Services

 

  • CRISPR/CAS9 based knockout in mouse, rat
  • ES cell based knockout in mouse

 

 

Knockin Services

 

  • CRISPR/CAS9 based knockin in mouse, rat
  • ES cell based knockin in mouse

 

 

Humanization Services

 

  • In situ replace mouse gene with matched human exons or introns
  • Express human cDNA under the control of mouse promoter

 

 

Transgenic Services

 

  • Random integration into genome
  • Targeted transgene into Rosa26 or other site

 

 

Genotyping and Phenotyping Services

 

  • Analyze the genotype of mice and cells by PCR, Southern Blot or NGS
  • Characterization of disease mouse models

 

 

Other Services

 

  • In vitro fertilization
  • Embryo and sperm cryopreservation

 

 

Compliance and Accreditations

 

  • AAALAC accredited facility
  • OECD – received a statement of GLP compliance from the Belgium regulatory authorities
  • Chinese SFDA – received certificate of GLP compliance
  • WuXi has conducted IND and NDA enabling studies for submission to the US FDA

 

 

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