Home Services & Solutions Hits Finding Discovery Biology In vitro Biology Enzymes/Biochemical Assays Ion Channel Cellular Assays GPCR, Transporter and NHR Radioactive Assays Cancer Cell Panel & In Vitro Oncology Assays In Vitro Assays for Diabetes and Other Metabolic Diseases High Throughput Screening High Content Platform In vivo Pharmacology & PK/PD Cardiovascular Diseases Metabolic Diseases Fibrosis: Lung, Liver, Kidney Central Nervous System & Pain Respiratory: Asthma & COPD IBS/IBD Animal Models Large Animal Disease Models Infectious Disease Antiviral Services Virology Assays Supporting Human Clinical Trials HBV Platform Safety and Early Toxicity In Vitro Safety Profiling for Medchem Support In Vitro Tox Assays for Medchem Support Early Stage Safety Assessment Oncology & Immunology CRISPR/Cas9 Gene Editing In Vitro & In Vivo Library Screening In Vivo CRISPR Animal Models and Services Gene Therapy Tumor Models Cell Line-Derived Xenograft (CDX) Tumor Models Patient-Derived Xenograft (PDX) Tumor Models Syngeneic Tumor Models Human Immune Checkpoint Gene KI Mouse Models hPBMC/HSC Humanized Models Immuno-oncology Translational Oncology Biomarker Discovery Biomarker Clinical Biomarker Autoimmune and Inflammatory Animal Models OncoWuXi Database Discovery Services Hits Finding Structure Based Drug Discovery Protein Production X-ray Crystallography CryoEM Biophysical Assays and Screening FBDD - Fragment Screening Biopharmaceutical Assays FTE Chemistry Services Technology Platform Specialty Chemistry Integrated Discovery Academic Discovery Biology Chemistry Analysis Separation Center Center of Natural Product Impurity Isolation and Identification Physicochemical Characterization & Others Pharmaceutical Analysis ASMS Screening Therapeutic Areas Cardiovascular Diseases Metabolic Diseases Fibrosis lung, liver, kidney Central Nervous System & Pain Respiratory: Asthma & COPD Infectious Disease Oncology & Immunology Autoimmune and Inflammatory Our Brand HD Biosciences Crelux DELopen DELight OncoWuXi About Us About WuXi AppTec Discovery Services Leadership About WuXi AppTec News & Events News Upcoming Events Resource Library Webinars Newsletter Latest Sciences Literature Download Contact
High Efficiency Genome Editing Service for Drug Discovery From genome editing to disease models and PK-PD-efficacy studies In Vivo CRISPR Platform for Rare Disease Well-established in vivo gene editing platform in rodent Generation of genetically engineered animal models (GEAM) for drug discovery in rare disease 30+ knockin and knockout mouse lines generated last year Efficacy Evaluation and MoA Research Platform Well-established in vitro, ex vivo and in vivo bioassay platforms Multiple routes for drug administration, animal and tissue manipulation and histopathology Knockout Services CRISPR/CAS9 based knockout in mouse, rat ES cell based knockout in mouse Knockin Services CRISPR/CAS9 based knockin in mouse, rat ES cell based knockin in mouse Humanization Services In situ replace mouse gene with matched human exons or introns Express human cDNA under the control of mouse promoter Transgenic Services Random integration into genome Targeted transgene into Rosa26 or other site Genotyping and Phenotyping Services Analyze the genotype of mice and cells by PCR, Southern Blot or NGS Characterization of disease mouse models Other Services In vitro fertilization Embryo and sperm cryopreservation Compliance and Accreditations AAALAC accredited facility OECD – received a statement of GLP compliance from the Belgium regulatory authorities Chinese SFDA – received certificate of GLP compliance WuXi has conducted IND and NDA enabling studies for submission to the US FDA Business Contact： North America: Declan Ryan, declan.ryan@wuxiapptec.com Europe and Israel: Dave Madge, dave_madge@wuxiapptec.com China: Marcher Xu, xu_longji@wuxiapptec.com Japan: Yan Zhu, yan_zhu@wuxiapptec.com Korea: Suk Young Cho, sycho@wuxiapptec.com
