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Autoimmune and inflammatory animal models

Overview

 

1) Autoimmune arthritis

  • Collagen induced arthritis (CIA) in DBA/1 mice
  • Adjuvant induced arthritis (AIA) in Lewis rats
  • hTNFα transgenic mice - a spontaneous model

2) Experimental autoimmune encephalomyelitis

3) Delayed type hypersensitivity (DTH)

  • Oxazolone-induced DTH in mice
  • DNFB-induced DTH in mice

4) Psoriasis-Imiquimod-induced psoriasis-like skin inflammation 

5) IBD-Naive T cell transfer induced Colitis

6) Systemic lupus erythematosus（SLE）in MRL mice

 

 

Rheumatoid Arthritis (RA) Models     

 

  • Collagen-induced arthritis (CIA) in DBA/1 mice
  • Collagen-induced arthritis (CIA) in Lewis rats
  • Adjuvant-induced arthritis (AIA) in Lewis rats
  • hTNFa transgenic mice

 

 

Multiple Sclerosis (MS) Models

 

  • MOG-induced (experimental autoimmune encephalomyelitis, EAE) in C57BL/6 mice
  • MBP-induced EAE in Lewis rats
  • PLP-induced relapsing-remitting EAE in SJL mice

 

 

Delayed Type Hypersensitivity (DTH) Models              

 

  • Oxazolone-induced DTH in mice
  • DNFB-induced DTH in mice

 

 

Psoriasis Model

 

  • Imiquimod-induced psoriasis-like skin inflammation in mice
  • IL-23-induced eczema in mice

 

 

Inflammatory Bowel Disease (IBD) Model

 

  • DSS-induced colitis in C57BL/6 mice
  • TNBS-induced colitis in mice

 

 

Gout Models

 

  • Oteracil potassium-induced hyperuricemia
  • MSU-induced air pouch inflammation

 

 

Acute Inflammation In Vivo

 

  • LPS-induced airway inflammation in Wistar rats
  • LPS-induced cytokine model in mice and rats
  • ConA-induced cytokine model in mice and rats
  • R848 (Resiquimod) induced cytokine model in mice and rats

 

 

In Vitro Assays

 

  • Cell based in vitro screening (PBMC)
  • Cell based in vitro screening (Cell line and Multiplex)

 

 

 

 Learn More About Oncology & Immunology

 

 

 

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