August 22, 2020, WuXi AppTec opened its first DEL Teaching Laboratory to support partners conducting DNA Encoded Library (DEL) screening. The new lab is located in Natick Massachusetts and operated by WuXi AppTec’s Hit Success (HitS) business unit. The lab is a multi-faceted screening and analytical facility with the express purpose of supporting successful learning and hit finding results for WuXi AppTec partners who are pursuing DNA encoded screening projects.
DNA-encoded library technology allows for the rapid synthesis of large chemical libraries of millions to billions of compounds. The billions of distinct library members of a DEL can then be screened to find novel chemical matter that binds to specific proteins. The structural information of the enriched molecules can then be analyzed according to the sequences of the linked DNA tags.
The classic click reaction is the copper-catalysed reaction of an azide with an alkyne to form a 5-membered heteroatom ring.
DNA-encoded library (DEL) is successful for hit identification and widely used in drug discovery.Machine learning is particularly valuable and promising towards DNA-encoded library (DEL) technology as its ability in building blocking selection.
DELFinder: An Efficient Academic Search Engine Dedicated to the DNA-Encoded Library Literature!
DNA-encoded chemical library (DECL) technology allows the rapid construction of large chemical libraries of typically millions to billions of compounds.
DNA-encoded libraries (DEL) have become a significant tool for the hit identification in drug discovery. DEL technology allows the rapid construction of large chemical libraries of typically millions to billions of compounds...
With the end of the extended Lunar New Year Holiday, WuXi AppTec, Research Service Division（RSD）sites in China have resumed operations today, with the exception of our site in Wuhan, which will reopen when local regulations permit.
On January 3, 2020, DELopen launched DELFinder, a DEL specific academic search engine designed to assist global drug researchers with locating relevant literature about DEL technology
SHANGHAI, CHINA; CAMBRIDGE, MASSACHUSETTS, USA; SANKT AUGUSTIN, GERMANY Oct 10, 2019 - WuXi AppTec Research Service Division and BioSolveIT today launched a ...