Recently, DELFinder——a DEL-related online database has helped Wolkenberg's team from Janssen Pharmaceuticals, Inc to complete a search of DEL-related publications, and the result was successfully published in the journal ACS Medicinal Chemistry Letters.
WuXi AppTec HitS unit today announced the opening of its DNA Encoded Library (DEL) Laboratory in Munich, Germany. This new lab will facilitate the European clients to get access to DEL technology and related research, accelerating the timeline for hit discovery and drug development.
WuXi AppTec and BioInnovation Institute (BII) have entered into a partnership agreement to help early-stage life science and biotech start-ups advance their research and translate ideas into innovative healthcare products.
DNA-encoded library (DEL) technology is a powerful and valuable tool commonly used by the pharmaceutical industry for the identification of compounds with affinity to biomolecular targets. Success in this endeavor lies in sampling diverse chemical libraries. However, current DNA-encoded library technology tend to be deficient in C(sp3) carbon counts.
DNA-encoded library technology allows for the rapid synthesis of large chemical libraries of millions to billions of compounds. The billions of distinct library members of a DEL can then be screened to find novel chemical matter that binds to specific proteins. The structural information of the enriched molecules can then be analyzed according to the sequences of the linked DNA tags.
The classic click reaction is the copper-catalysed reaction of an azide with an alkyne to form a 5-membered heteroatom ring.
DNA-encoded library (DEL) is successful for hit identification and widely used in drug discovery.Machine learning is particularly valuable and promising towards DNA-encoded library (DEL) technology as its ability in building blocking selection.
DELFinder: An Efficient Academic Search Engine Dedicated to the DNA-Encoded Library Literature!
DNA-encoded chemical library (DECL) technology allows the rapid construction of large chemical libraries of typically millions to billions of compounds.
DNA-encoded libraries (DEL) have become a significant tool for the hit identification in drug discovery. DEL technology allows the rapid construction of large chemical libraries of typically millions to billions of compounds...
With the end of the extended Lunar New Year Holiday, WuXi AppTec, Research Service Division（RSD）sites in China have resumed operations today, with the exception of our site in Wuhan, which will reopen when local regulations permit.
On January 3, 2020, DELopen launched DELFinder, a DEL specific academic search engine designed to assist global drug researchers with locating relevant literature about DEL technology
SHANGHAI, CHINA; CAMBRIDGE, MASSACHUSETTS, USA; SANKT AUGUSTIN, GERMANY Oct 10, 2019 - WuXi AppTec Research Service Division and BioSolveIT today launched a ...