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IDSU Integrated Medchem Programs We offer comprehensive end-to-end solutions for creating, identifying, and supporting preclinical candidates, from discovery to development, with our integrated chemistry and biology research platform Hits Identification Target validation HTS- novel/ focused libraries DNA-Encoded Libraries High quality protein production Fragment screening and biophysical hit finding X-ray crystallography CADD (molecular docking, homology modeling, pharmacophore modeling, core hopping, virtual screening) MedChem and Synthetic Chemistry Medchem design Synthetic chemistry- special chemistry platform, unique scaffolds/ building blocks, high throughput synthesis/ purification Large scale SFC/ chiral separation. Impurity isolation and identification Project management Compound management Deliver preclinical candidates In vitro and In vivo Biology Multiple biology screening platform Infectious disease platform Specialty models including NASH CRISPR, targeted oncology (PDX), immuno-oncology, translational oncology Autoimmune and inflammatory diseases Electrophysiology DMPK In vitro/ In vivo ADME Preformulation Bioanalytical method development Rodents to NHPs PK PD models In vivo PK/ PD (Biomarkers) Metabolite ID Radiolabeled studies Mass Balance Discovery to IND-enabling (FDA, CFDA, EMA) Tox Non-GLP and GLP Safety pharmacology Genetic & in vitro toxicology Developmental & reproductive toxicology Ocular toxicology Toxicokinetcis & bioanalytical analysis Pathology Business Contact: North America: Declan Ryan, declan.ryan@wuxiapptec.com Europe and Israel: Dave Madge, dave_madge@wuxiapptec.com China: Marcher Xu, xu_longji@wuxiapptec.com Japan: Yan Zhu, yan_zhu@wuxiapptec.com Korea: Suk Young Cho, sycho@wuxiapptec.com