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Integrated Discovery

IDSU Integrated Medchem Programs

 

We offer comprehensive end-to-end solutions for creating, identifying, and supporting preclinical candidates, from discovery to development, with our integrated chemistry and biology research platform

 

Hits Identification

 

  • Target validation
  • HTS- novel/ focused libraries
  • DNA-Encoded Libraries
  • High quality protein production
  • Fragment screening and biophysical hit finding
  • X-ray crystallography
  • CADD (molecular docking, homology modeling, pharmacophore modeling, core hopping, virtual screening)

 

MedChem and Synthetic Chemistry

 

  • Medchem design
  • Synthetic chemistry- special chemistry platform, unique scaffolds/ building blocks, high throughput synthesis/ purification
  • Large scale SFC/ chiral separation. Impurity isolation and identification
  • Project management
  • Compound management
  • Deliver preclinical candidates

 

In vitro and In vivo Biology

 

  • Multiple biology screening platform
  • Infectious disease platform
  • Specialty models including NASH
  • CRISPR, targeted oncology (PDX), immuno-oncology, translational oncology
  • Autoimmune and inflammatory diseases
  • Electrophysiology

 

DMPK

 

  • In vitro/ In vivo ADME
  • Preformulation
  • Bioanalytical method development
  • Rodents to NHPs PK
  • PD models
  • In vivo PK/ PD (Biomarkers)
  • Metabolite ID
  • Radiolabeled studies
  • Mass Balance
  • Discovery to IND-enabling (FDA, CFDA, EMA)

 

Tox

 

  • Non-GLP and GLP
  • Safety pharmacology
  • Genetic & in vitro toxicology
  • Developmental & reproductive toxicology
  • Ocular toxicology
  • Toxicokinetcis & bioanalytical analysis
  • Pathology

 

 

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